Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion
Synaptotagmin-1 (Syt1) acts as a Ca2+ sensor for neurotransmitter release through its C2 domains.It has been proposed that Syt1 promotes SNARE-dependent fusion mainly through its C2B domain, but the underlying mechanism is poorly understood.In this study, we show that the C2B neon catsuit domain interacts simultaneously with acidic membranes and SN